Thanks for your observations Peter. Things, however, just got weirder and weirder. I once again uninstalled and reinstalled FS9, along with FSUIPC 3.45, and then applied Microsoft's update. Now this time around all seems fine.
I suspect you may be right about some other program in memory is the cause of the problem - and intermittently at that it appears. Seems I may have to be more ruthless than normal about what is running in the background when I start my gaming. My usual routine before starting a games session is to shut down virus checker and then right click on all the icons in my system tray and shut down all that have the ability to be shut down manually.
I'm about to install my favourite add-on aircraft, Flight1's Piper Meredian, which was also having problems with the GNS530 gps being slow to respond. If the problem rears its ugly head again I'll have to delve into the Task Manager and set about disabling the unessential hidden processes. Hopefully I'll discover the issue and will post back with my solution.